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human TIGIT shRNA silencing Adenovirus

Name 
Ad-h-TIGIT-shRNA
Cat No 
shADV-225501
Availability
Immediate
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human TIGIT.

shADV-225501
Ad-h-TIGIT-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human TIGIT (T-cell immunoreceptor with Ig and ITIM domains). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
T-cell immunoreceptor with Ig and ITIM domains; V-set and immunoglobulin domain containing 9; V-set and immunoglobulin domain-containing protein 9; V-set and transmembrane domain containing 3; V-set and transmembrane domain-containing protein 3; VSIG9; VSIG9, VSTM3; VSTM3; Washington University cell adhesion molecule; WUCAM
Description (eCommerce)
TIGIT is a member of the PVR (poliovirus receptor) family of immunoglobin proteins and is expressed on several classes of T cells including follicular B helper T cells (TFH). TIGIT has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses. [taken from NCBI Entrez Gene (Gene ID: 201633)].
Description (Vector)
TIGIT encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses.
Gene ID
201633
Gene Name (eCommerce)
T cell immunoreceptor with Ig and ITIM domains
Gene Name (Vector)
T-cell immunoreceptor with Ig and ITIM domains
Gene Symbol
TIGIT
HGNC ID
HGNC:26838
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
735
Protein Name (eCommerce)
T-cell immunoreceptor with Ig and ITIM domains
RefSeq ID
NM_173799
RefSeq Synonyms
NM_173799, BC101291, BC101290, BC101289, BC101288,
Research Areas
Immunology,Signal Transduction,immunology,cell_biology
Research Areas (Faceted)
cell_biology,immunology,signal_transduction
Species
human
Target Sentence
TIGIT is a member of the PVR (poliovirus receptor) family of immunoglobin proteins and is expressed on several classes of T cells including follicular B helper T cells (TFH). TIGIT has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses. [taken from NCBI Entrez Gene (Gene ID: 201633)].
UniGene ID
Hs.421750
UniProt ID (eCommerce)
Q495A1

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.