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human TIGIT Over-expression AAV

Name 
AAV-h-TIGIT
Cat No 
AAV-225501
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human TIGIT.

AAV-225501
AAV-h-TIGIT

Ready-to-use AAV expressing Human TIGIT (T-cell immunoreceptor with Ig and ITIM domains). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
T-cell immunoreceptor with Ig and ITIM domains; V-set and immunoglobulin domain containing 9; V-set and immunoglobulin domain-containing protein 9; V-set and transmembrane domain containing 3; V-set and transmembrane domain-containing protein 3; VSIG9; VSIG9, VSTM3; VSTM3; Washington University cell adhesion molecule; WUCAM
Description (eCommerce)
TIGIT is a member of the PVR (poliovirus receptor) family of immunoglobin proteins and is expressed on several classes of T cells including follicular B helper T cells (TFH). TIGIT has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses. [taken from NCBI Entrez Gene (Gene ID: 201633)].
Description (Vector)
TIGIT encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses.
Gene ID
201633
Gene Name (eCommerce)
T cell immunoreceptor with Ig and ITIM domains
Gene Name (Vector)
T-cell immunoreceptor with Ig and ITIM domains
Gene Symbol
TIGIT
HGNC ID
HGNC:26838
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
735
Protein Name (eCommerce)
T-cell immunoreceptor with Ig and ITIM domains
RefSeq ID
NM_173799
RefSeq Synonyms
NM_173799, BC101291, BC101290, BC101289, BC101288,
Research Areas
Immunology,Signal Transduction,immunology,cell_biology
Research Areas (Faceted)
cell_biology,immunology,signal_transduction
Species
human
Target Sentence
TIGIT is a member of the PVR (poliovirus receptor) family of immunoglobin proteins and is expressed on several classes of T cells including follicular B helper T cells (TFH). TIGIT has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses. [taken from NCBI Entrez Gene (Gene ID: 201633)].
UniGene ID
Hs.421750
UniProt ID (eCommerce)
Q495A1

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.