human TBP shRNA silencing Adenovirus

GTF2D; GTF2D1; HDL4; SCA17; TATA sequence-binding protein; TATA-binding factor; TATA-box binding protein N-terminal domain; TATA-box factor; TATA-box-binding protein; TFIID; transcription initiation factor TFIID TBP subunit

TBP (TATA-box-binding protein) is a key component of the multiprotein transcription factor TFIID (transcription factor IID) which binds to core promoters and activates RNA polymerase II transcription. TBP is responsible for directing TFIID binding to the TATA-box to form the pre-initiation transcriptional complex. Mutations in the polyglutamine tract of TBP are associated with the neurodegenerative disorder spinocerebellar ataxia 17.

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminus. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. The number of CAG repeats encoding the polyglutamine tract is usually 32-39, and expansion of the number of repeats increases the length of the polyglutamine string and is associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease. Two transcript variants encoding different isoforms have been found for this gene.

6908

TATA-box binding protein

TATA-box binding protein

TBP

HGNC:11588

9606.0

867

867 bp

TATA-box-binding protein

NM_003194

NM_003194, NM_001172085, BC110341, BC109054, BC109053,

Apoptosis,Cancer,Epigenetic Regulation of Gene Expression,Gene Expression,Host-Virus Interactions,Huntington's Disease,Neurobiology,Neurodegeneration,Spermatogenesis,Transcription Factor/Regulator,Viral Carcinogenesis

cancer,cell_biology,developmental_biology,genetics,infectious_disease,neurobiology,transcription_translation

human

TBP (TATA-box-binding protein) is a key component of the multiprotein transcription factor TFIID (transcription factor IID) which binds to core promoters and activates RNA polymerase II transcription. TBP is responsible for directing TFIID binding to the TATA-box to form the pre-initiation transcriptional complex. Mutations in the polyglutamine tract of TBP are associated with the neurodegenerative disorder spinocerebellar ataxia 17.

Hs.590872

P20226