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human TAP2 shRNA silencing Adenovirus

Name 
Ad-h-TAP2-shRNA
Cat No 
shADV-224967
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human TAP2.

shADV-224967
Ad-h-TAP2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human TAP2 (transporter 2, ATP binding cassette subfamily B member). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
ABC18; ABCB3; APT2; D6S217E; PSF-2; PSF2; RING11
Description (Vector)
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces two products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules.
Gene ID
6891
Gene Name (Vector)
transporter 2, ATP binding cassette subfamily B member
Gene Symbol
TAP2
HGNC ID
HGNC:44
ORF Size (aa)
2109
ORF Size (bp)
2109 bp
RefSeq ID
NM_000544
RefSeq Synonyms
NM_018833, NM_001290043, NM_000544, BC152839, BC002751,
Species
human
UniGene ID
Hs.502

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.