human TAF6 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human TAF6.
shADV-224928
Ad-h-TAF6-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human TAF6 (TATA-box binding protein associated factor 6). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ALYUS; MGC:8964; RNA polymerase II TBP-associated factor subunit E; TAF(II)70; TAF(II)80; TAF2E; TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa; TAFII70; TAFII-70; TAFII80; TAFII-80; TAFII85; TATA box binding protein (TBP)-associated factor, RNA polymerase II, E, 70/85kD; transcription initiation factor TFIID 70 kDa subunit; Transcription initiation factor TFIID 80 kDa subunit; transcription initiation factor TFIID subunit 6
Description (eCommerce)
The TFIID complex is important for coordinating the pre-initiation complex and transcription by RNA Pol II. The complex contains the TFIID protein, TATA binding protein (TBP) and multiple TBP-associated factors (TAFs). TAF6 is also known as TAFII70 and is a TAF implicated in p53-mediated transcription. TAF6 exists as multiple splice variant isoforms and may play an important role in breast cancer cell growth.
Description (Vector)
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds weakly to TBP but strongly to TAF1, the largest subunit of TFIID. Alternative splicing results in multiple transcript variants.
Gene ID
6878
Gene Name (eCommerce)
TATA-box binding protein associated factor 6
Gene Name (Vector)
TATA-box binding protein associated factor 6
Gene Symbol
TAF6
HGNC ID
HGNC:11540
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2034
ORF Size (bp)
2034 bp
Protein Name (eCommerce)
Transcription initiation factor TFIID subunit 6
RefSeq ID
NM_005641
RefSeq Synonyms
NM_139315, NM_005641, NM_001190415, BC018115,
Research Areas
Cell Cycle,Gene Expression,Host-Virus Interactions,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,transcription_translation,infectious_disease
Species
human
Target Sentence
The TFIID complex is important for coordinating the pre-initiation complex and transcription by RNA Pol II. The complex contains the TFIID protein, TATA binding protein (TBP) and multiple TBP-associated factors (TAFs). TAF6 is also known as TAFII70 and is a TAF implicated in p53-mediated transcription. TAF6 exists as multiple splice variant isoforms and may play an important role in breast cancer cell growth.
UniGene ID
Hs.489309
UniProt ID (eCommerce)
P49848
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.