human MAP3K7 Over-expression AAV

CSCF; FMD2; MEKK7; mitogen-activated protein kinase kinase kinase 7; TAK1; TGF1a; TGF-beta activated kinase 1; TGF-beta-activated kinase 1; transforming growth factor-beta-activated kinase 1

TAK1 (TGF-beta activated kinase 1) is also called mitogen-activated protein kinase kinase kinase 7 (MAP3K7). TAK1 is a serine/threonine protein kinase that mediates signals transduced by proinflammatory cytokines such as TGF-beta, tumor necrosis factor (TNF), interleukin-1 (IL-1) and wnt family ligands. TAK1 transduces signals by stimulating a MAPK pathway that ultimately stimulates JNK (c-terminal jun kinase) and p38 MAPKs. TAK1 is also an activator of the Ikappa B kinase that leads to the activation of NFkappa-B.

MAP3K7 is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

6885

mitogen-activated protein kinase kinase kinase 7

mitogen-activated protein kinase kinase kinase 7

MAP3K7

HGNC:6859

9606.0

1740

1740 bp

Mitogen-activated protein kinase kinase kinase 7

NM_145332

NM_145333, NM_145332, NM_145331, NM_003188, BC017715,

Angiogenesis,Apoptosis,B-cell Receptor Signaling,Cardiology,Cardiovascular,CD95/FAS Signaling,Cytokine Signaling,DNA Damage/Repair,EPO Signaling,Fc Receptor Signaling,Histone Modification,Host-Virus Interactions,Immunology,Innate Immunity,Insulin Signaling,Interleukin Signaling,JAK-STAT Signaling,JNK Signaling,Kinase/Phosphatase,MAPK Signaling,Neurobiology,Neurodevelopment,NF-kB Signaling,Notch Signaling,RANKL-RANK Signaling,Signal Transduction,T-cell Receptor Signaling,TGF-beta Signaling,TNF Signaling,Toll-like Receptor Signaling,Transcription Factor/Regulator,TWEAK Signaling,VEGF Signaling,Wnt Signaling

cancer,cardiovascular,cell_biology,developmental_biology,genetics,immunology,infectious_disease,neurobiology,signal_transduction,transcription_translation

human

TAK1 (TGF-beta activated kinase 1) is also called mitogen-activated protein kinase kinase kinase 7 (MAP3K7). TAK1 is a serine/threonine protein kinase that mediates signals transduced by proinflammatory cytokines such as TGF-beta, tumor necrosis factor (TNF), interleukin-1 (IL-1) and wnt family ligands. TAK1 transduces signals by stimulating a MAPK pathway that ultimately stimulates JNK (c-terminal jun kinase) and p38 MAPKs. TAK1 is also an activator of the Ikappa B kinase that leads to the activation of NFkappa-B.

Hs.644143

O43318