human STUB1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human STUB1.
shADV-224646
Ad-h-STUB1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human STUB1 (STIP1 homology and U-box containing protein 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
antigen NY-CO-7; carboxy terminus of Hsp70-interacting protein; CHIP; CLL-associated antigen KW-8; E3 ubiquitin-protein ligase CHIP; heat shock protein A binding protein 2 (c-terminal); HSPABP2; NY-CO-7; RING-type E3 ubiquitin transferase CHIP; SCAR16; SDCCAG7; serologically defined colon cancer antigen 7; STIP1 homology and U box-containing protein 1; STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase; UBOX1
Description (eCommerce)
STUB1/CHIP is an E3 ubiquitin ligase and co-chaperone of heat-shock protein 70 (Hsp70). STUB1/CHIP interacts with Hsp70 to monitor protein folding and direct misfolded proteins for proteasomal degradation. It has been found to also associate with Hsp90 to remove phosphorylated protein tau, a protein that accumulates in the brains of Alzheimers and Down’s syndrome patients. STUB1/CHIP has been reported to also have intrinsic chaperone activity and recognize non-native proteins in response to heat stress. In this way, STUB1/CHIP has been shown to be a direct chaperone for p53.
Description (Vector)
STUB1, or CHIP, is a ubiquitin ligase/cochaperone that participates in protein quality control by targeting a broad range of chaperone protein substrates for degradation (Min et al., 2008 (PubMed 18411298)).(supplied by OMIM, Jul 2009)
Gene ID
10273
Gene Name (eCommerce)
STIP1 homology and U-box containing protein 1
Gene Name (Vector)
STIP1 homology and U-box containing protein 1
Gene Symbol
STUB1
HGNC ID
HGNC:11427
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
912
Protein Name (eCommerce)
E3 ubiquitin-protein ligase CHIP
RefSeq ID
NM_005861
RefSeq Synonyms
NM_005861, NM_001293197, BC063617, BC022788, BC017178, BC007545,
Research Areas
Aging,Antigen Processing and Presentation,DNA Damage/Repair,Immunology,Neurobiology,Neurodegeneration,Parkinson's Disease,Parkin-Ubiquitin Proteasomal System,Signal Transduction,TGF-beta Signaling,Ubiquitination
Research Areas (Faceted)
cell_biology,genetics,transcription_translation,immunology,neurobiology,signal_transduction
Species
human
Target Sentence
STUB1/CHIP is an E3 ubiquitin ligase and co-chaperone of heat-shock protein 70 (Hsp70). STUB1/CHIP interacts with Hsp70 to monitor protein folding and direct misfolded proteins for proteasomal degradation. It has been found to also associate with Hsp90 to remove phosphorylated protein tau, a protein that accumulates in the brains of Alzheimers and Down’s syndrome patients. STUB1/CHIP has been reported to also have intrinsic chaperone activity and recognize non-native proteins in response to heat stress. In this way, STUB1/CHIP has been shown to be a direct chaperone for p53.
UniGene ID
Hs.592081
UniProt ID (eCommerce)
Q9UNE7
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.