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human SSB shRNA silencing Adenovirus

Name 
Ad-h-SSB-shRNA
Cat No 
shADV-224380
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human SSB.

shADV-224380
Ad-h-SSB-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human SSB (Sjogren syndrome antigen B). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
autoantigen La; La; la autoantigen; La ribonucleoprotein; La ribonucleoprotein domain family, member 3; La/SSB; LARP3; lupus La antigen; lupus La protein; sjoegren syndrome type B antigen; SS-B; SS-B/La protein
Description (eCommerce)
Sjogren syndrome antigen B (autoantigen La) (SS-B) is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus [taken from NCBI Entrez Gene (Gene ID: 6741)].
Description (Vector)
SSB is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus.
Gene ID
6741
Gene Name (eCommerce)
Sjogren syndrome antigen B
Gene Name (Vector)
Sjogren syndrome antigen B
Gene Symbol
SSB
HGNC ID
HGNC:11316
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1227
ORF Size (bp)
1227 bp
Protein Name (eCommerce)
Lupus La protein
RefSeq ID
NM_003142
RefSeq Synonyms
NM_003142, NM_001294145, BC020818, BC001289,
Research Areas
Gene Expression,Metabolism/Metabolic Process,mRNA Binding,RNA Binding,RNA Processing,tRNA Binding
Research Areas (Faceted)
cell_biology,genetics,metabolism,transcription_translation
Species
human
Target Sentence
Sjogren syndrome antigen B (autoantigen La) (SS-B) is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus [taken from NCBI Entrez Gene (Gene ID: 6741)].
UniGene ID
Hs.632535
UniProt ID (eCommerce)
P05455

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.