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human SPAG8 shRNA silencing Adenovirus

Name 
Ad-h-SPAG8-shRNA
Cat No 
shADV-224071
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human SPAG8.

shADV-224071
Ad-h-SPAG8-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human SPAG8 (sperm associated antigen 8). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
BS-84; CILD28; CT142; HSD-1; hSMP-1; SMP1; SPAG3
Description (Vector)
The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein encoded by this gene is recognized by sperm agglutinating antibodies from an infertile woman. This protein is localized in germ cells of the testis at all stages of spermatogenesis and is localized to the acrosomal region of mature spermatozoa. This protein interacts with ACT (activator of CREM in testis) and may play a role in CREM (cAMP response element modulator)-ACT-mediated gene transcription during spermatogenesis. This protein may also play a role in spermatogenesis by regulating microtubule formation and cell division. Alternatively spliced variants that encode different protein isoforms have been described but the full-length sequences of only two have been determined.
Gene ID
26206
Gene Name (Vector)
sperm associated antigen 8
Gene Symbol
SPAG8
HGNC ID
HGNC:14105
ORF Size (aa)
1506
ORF Size (bp)
1506 bp
RefSeq ID
NM_172312
RefSeq Synonyms
NM_172312, NM_001039592, BC019247,
Species
human
UniGene ID
Hs.256747

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.