human MAML2 Over-expression AAV

Name 
AAV-h-MAML2
Cat No 
AAV-214868
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human MAML2.

AAV-214868
AAV-h-MAML2

Ready-to-use AAV expressing Human MAML2 (mastermind like transcriptional coactivator 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
MAM2; mam-2; MAM3; MAM-3; mastermind-like 2; mastermind-like protein 2; MLL-MAML2
Description (eCommerce)
There are 3 MAML (mastermind-like) proteins in mammals (MAML1-3). MAML2 is a critical coactivator for NOTCH signaling. MAML2 associates with NOTCH and CSL in a ternary complex and functions to activate transcription of HES and hairy-related basic helix-loop-helix transcription factors. MAML2 has been identified in a chromosomal rearrangement and fusion with MECT1 in mucoepidermoid carcinomas, secondary acute myeloid leukemia, hidradenomas, and myelodysplastic syndrome. MECT1 is a CREB regulator, and when fused with the transactivational domain of MAML2, imparts constitutive activation of CREB-dependent transcription that may promote oncogenesis.
Gene ID
84441
Gene Name (eCommerce)
mastermind like transcriptional coactivator 2
Gene Name (Vector)
mastermind like transcriptional coactivator 2
Gene Symbol
MAML2
HGNC ID
HGNC:16259
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3459
ORF Size (bp)
3459 bp
Protein Name (eCommerce)
Mastermind-like protein 2
RefSeq ID
NM_032427
RefSeq Synonyms
NM_032427, BC152449, BC143529,
Research Areas
Cancer,Gene Expression,Golgi Apparatus,Notch Signaling,Nuclear Receptor Coactivators,Signal Transduction,TGF-beta Signaling,Transcription Factor/Regulator
Research Areas (Faceted)
cancer,cell_biology,developmental_biology,immunology,signal_transduction,transcription_translation
Species
human
Target Sentence
There are 3 MAML (mastermind-like) proteins in mammals (MAML1-3). MAML2 is a critical coactivator for NOTCH signaling. MAML2 associates with NOTCH and CSL in a ternary complex and functions to activate transcription of HES and hairy-related basic helix-loop-helix transcription factors. MAML2 has been identified in a chromosomal rearrangement and fusion with MECT1 in mucoepidermoid carcinomas, secondary acute myeloid leukemia, hidradenomas, and myelodysplastic syndrome. MECT1 is a CREB regulator, and when fused with the transactivational domain of MAML2, imparts constitutive activation of CREB-dependent transcription that may promote oncogenesis.
UniGene ID
Hs.428214
UniProt ID (eCommerce)
Q8IZL2

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.