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human MAML2 shRNA silencing Adenovirus

Name 
Ad-h-MAML2-shRNA
Cat No 
shADV-214868
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human MAML2.

shADV-214868
Ad-h-MAML2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human MAML2 (mastermind like transcriptional coactivator 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
MAM2; mam-2; MAM3; MAM-3; mastermind-like 2; mastermind-like protein 2; MLL-MAML2
Description (eCommerce)
There are 3 MAML (mastermind-like) proteins in mammals (MAML1-3). MAML2 is a critical coactivator for NOTCH signaling. MAML2 associates with NOTCH and CSL in a ternary complex and functions to activate transcription of HES and hairy-related basic helix-loop-helix transcription factors. MAML2 has been identified in a chromosomal rearrangement and fusion with MECT1 in mucoepidermoid carcinomas, secondary acute myeloid leukemia, hidradenomas, and myelodysplastic syndrome. MECT1 is a CREB regulator, and when fused with the transactivational domain of MAML2, imparts constitutive activation of CREB-dependent transcription that may promote oncogenesis.
Gene ID
84441
Gene Name (eCommerce)
mastermind like transcriptional coactivator 2
Gene Name (Vector)
mastermind like transcriptional coactivator 2
Gene Symbol
MAML2
HGNC ID
HGNC:16259
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3459
ORF Size (bp)
3459 bp
Protein Name (eCommerce)
Mastermind-like protein 2
RefSeq ID
NM_032427
RefSeq Synonyms
NM_032427, BC152449, BC143529,
Research Areas
Cancer,Gene Expression,Golgi Apparatus,Notch Signaling,Nuclear Receptor Coactivators,Signal Transduction,TGF-beta Signaling,Transcription Factor/Regulator
Research Areas (Faceted)
cancer,cell_biology,developmental_biology,immunology,signal_transduction,transcription_translation
Species
human
Target Sentence
There are 3 MAML (mastermind-like) proteins in mammals (MAML1-3). MAML2 is a critical coactivator for NOTCH signaling. MAML2 associates with NOTCH and CSL in a ternary complex and functions to activate transcription of HES and hairy-related basic helix-loop-helix transcription factors. MAML2 has been identified in a chromosomal rearrangement and fusion with MECT1 in mucoepidermoid carcinomas, secondary acute myeloid leukemia, hidradenomas, and myelodysplastic syndrome. MECT1 is a CREB regulator, and when fused with the transactivational domain of MAML2, imparts constitutive activation of CREB-dependent transcription that may promote oncogenesis.
UniGene ID
Hs.428214
UniProt ID (eCommerce)
Q8IZL2

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.