human SORT1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human SORT1.
shADV-224000
Ad-h-SORT1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human SORT1 (sortilin 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Gp95; LDLCQ6; NT3; NTR3
Description (Vector)
SORT1 encodes a protein that is a multi-ligand type-1 receptor with similarity to the yeast carboxypeptidase Y sorting receptor Vps10 protein. The encoded protein, a trans-Golgi network (TGN) transmembrane protein, binds a number of unrelated ligands that participate in a wide range of cellular processes; however, it lacks the typical features of a signalling receptor. In the TGN, furin mediates the activation of the mature binding form. The encoded protein consists of a large luminal domain, a single transmembrane segment and short C-terminal cytoplasmic tail. The luminal domain contains a cysteine-rich region similar to two corresponding segments in the yeast Vps10p; the cytoplasmic tail is similar to the corresponding segment of the cation-independent mannose 6-phosphate receptor and the tail also interacts with the VHS domains of GGA (Golgi-associated, gamma-adaptin homologous, ARF-interacting) proteins.
Gene ID
6272
Gene Name (Vector)
sortilin 1
Gene Symbol
SORT1
HGNC ID
HGNC:11186
ORF Size (aa)
2496
ORF Size (bp)
2496 bp
RefSeq ID
NM_002959
RefSeq Synonyms
NM_002959, NM_001205228, BC023542,
Species
human
UniGene ID
Hs.703487
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.