human SOCS2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human SOCS2.
shADV-223974
Ad-h-SOCS2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human SOCS2 (suppressor of cytokine signaling 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CIS2; Cish2; SOCS-2; SSI-2; SSI2; STATI2
Description (Vector)
SOCS2 encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. SOCS2 has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants.
Gene ID
8835
Gene Name (Vector)
suppressor of cytokine signaling 2
Gene Symbol
SOCS2
HGNC ID
HGNC:19382
ORF Size (aa)
597
RefSeq ID
NM_003877
RefSeq Synonyms
NM_003877, NM_001270471, NM_001270470, NM_001270469, NM_001270468, NM_001270467, BC010399,
Species
human
UniGene ID
Hs.485572
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.