human SNAI2 shRNA silencing Adenovirus

Name 
Ad-h-SNAI2-shRNA
Cat No 
shADV-223804
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human SNAI2.

shADV-223804
Ad-h-SNAI2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human SNAI2 (snail family transcriptional repressor 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
60
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
neural crest transcription factor SLUG; protein snail homolog 2; SLUG; slug (chicken homolog), zinc finger protein; SLUGH; SLUGH1; snail family zinc finger 2; snail homolog 2; SNAIL2; WS2D; zinc finger protein SNAI2
Description (eCommerce)
Slug is a member of the Snail family of C2H2-type zinc finger transcription factors. It acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. Slug is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. [taken from NCBI Entrez Gene (Gene ID: 6591)].
Description (Vector)
SNAI2 encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects.
Gene ID
6591
Gene Name (eCommerce)
snail family transcriptional repressor 2
Gene Name (Vector)
snail family transcriptional repressor 2
Gene Symbol
SNAI2
HGNC ID
HGNC:11094
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
807
Protein Name (eCommerce)
Zinc finger protein SNAI2
RefSeq ID
NM_003068
RefSeq Synonyms
NM_003068, BC015895, BC014890,
Research Areas
Apoptosis,Breast Cancer,Cancer,DNA Damage/Repair,Hippo Signaling,Histone Modification,Neurobiology,Neurodevelopment,Notch Signaling,SCF-KIT Signaling,Signal Transduction,Transcription Factor/Regulator,Wnt Signaling,Zinc-finger
Research Areas (Faceted)
cancer,signal_transduction,cell_biology,genetics,transcription_translation,signal_transduction,developmental_biology,genetics,neurobiology,developmental_biology,developmental_biology,signal_transduction,stem_cell_biology,genetics,transcription_translation,signal_transduction,developmental_biology,cell_biology
Species
human
Target Sentence
Slug is a member of the Snail family of C2H2-type zinc finger transcription factors. It acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. Slug is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. [taken from NCBI Entrez Gene (Gene ID: 6591)].
UniGene ID
Hs.360174
UniProt ID (eCommerce)
O43623

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.