human SETMAR shRNA silencing Adenovirus

Name 
Ad-h-SETMAR-shRNA
Cat No 
shADV-222744
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human SETMAR.

shADV-222744
Ad-h-SETMAR-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human SETMAR (SET domain and mariner transposase fusion gene). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
Histone-lysine N-methyltransferase; histone-lysine N-methyltransferase SETMAR; Mar1; METNASE; SET domain and mariner transposase fusion gene-containing protein; SET domain and mariner transposase fusion protein
Description (eCommerce)
Metnase is also known as Histone-lysine N-methyltransferase SETMAR. Metnase is a histone methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3, 2 specific tags for epigenetic transcriptional activation. Metanase specifically mediates dimethylation of H3 'Lys-36', and has sequence-specific DNA-binding activity and recognizes the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element. Metnase possessess DNA nicking activity and in vivo end joining activity, and it may mediate genomic integration of foreign DNA [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q53H47].
Gene ID
6419
Gene Name (eCommerce)
SET domain and mariner transposase fusion gene
Gene Name (Vector)
SET domain and mariner transposase fusion gene
Gene Symbol
SETMAR
HGNC ID
HGNC:10762
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1059
ORF Size (bp)
1059 bp
Protein Name (eCommerce)
Histone-lysine N-methyltransferase SETMAR
RefSeq ID
NM_006515
RefSeq Synonyms
NM_006515, NM_001320678, NM_001320677, NM_001320676, NM_001276325, NM_001243723, BC011635,
Research Areas
Cell Cycle,Chromatin Remodeling,DNA Damage/Repair,Histone Modification,Methyltransferase,Neurobiology
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,transcription_translation,cell_biology,neurobiology
Species
human
Target Sentence
Metnase is also known as Histone-lysine N-methyltransferase SETMAR. Metnase is a histone methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3, 2 specific tags for epigenetic transcriptional activation. Metanase specifically mediates dimethylation of H3 'Lys-36', and has sequence-specific DNA-binding activity and recognizes the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element. Metnase possessess DNA nicking activity and in vivo end joining activity, and it may mediate genomic integration of foreign DNA [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q53H47].
UniGene ID
Hs.475300
UniProt ID (eCommerce)
Q53H47

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.