human SEPT5 shRNA silencing Adenovirus

Name
Ad-h-SEPT5-shRNA

Cat No
shADV-222607

Availability
7-8 weeks

This is an Adenovirus expressing shRNA for silencing of Human SEPT5.

shADV-222607

Ad-h-SEPT5-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human SEPT5 (septin 5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Validated

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

CDCREL; CDCREL-1; CDCREL1; H5; HCDCREL-1; PNUTL1

Description (Vector)

5-Sep is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. 5-Sep is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced.

Gene ID

5413

Gene Name (Vector)

septin 5

Gene Symbol

5-Sep

HGNC ID

HGNC:9164

ORF Size (aa)

1110

ORF Size (bp)

1110 bp

RefSeq ID

NM_002688

RefSeq Synonyms

NM_002688, NM_001009939, BC025261,

Species

human

UniGene ID

Hs.283743

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.