human SEMA4A shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human SEMA4A.
shADV-222549
Ad-h-SEMA4A-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human SEMA4A (semaphorin 4A). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CORD10; RP35; SEMAB; SEMB
Description (Vector)
SEMA4A encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Mutations in this gene are associated with retinal degenerative diseases including retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
Gene ID
64218
Gene Name (Vector)
semaphorin 4A
Gene Symbol
SEMA4A
HGNC ID
HGNC:10729
ORF Size (aa)
2286
ORF Size (bp)
2286 bp
RefSeq ID
NM_022367
RefSeq Synonyms
NM_022367, NM_001193302, NM_001193301, NM_001193300, BC020974,
Species
human
UniGene ID
Hs.408846
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.