human RRM1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human RRM1.
shADV-222002
Ad-h-RRM1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human RRM1 (ribonucleotide reductase catalytic subunit M1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
R1; ribonucleoside-diphosphate reductase large subunit; ribonucleoside-diphosphate reductase subunit M1; Ribonucleotide reductase large subunit; ribonucleotide reductase M1 polypeptide; ribonucleotide reductase, R1 subunit; RIR1; RR1
Description (eCommerce)
RRM1 is the ribonucleoside-diphosphate reductase large subunit essential for the conversion of ribonucleotides into deoxyribonucleotides [taken from NCBI Entrez Gene (Gene ID: 6240)].
Description (Vector)
RRM1 encodes one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. RRM1 may play a role in malignancies and disease that involve this region.
Gene ID
6240
Gene Name (eCommerce)
ribonucleotide reductase catalytic subunit M1
Gene Name (Vector)
ribonucleotide reductase catalytic subunit M1
Gene Symbol
RRM1
HGNC ID
HGNC:10451
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2379
ORF Size (bp)
2379 bp
Protein Name (eCommerce)
Ribonucleoside-diphosphate reductase large subunit
RefSeq ID
NM_001033
RefSeq Synonyms
NM_001330193, NM_001318065, NM_001318064, NM_001033, BC006498,
Research Areas
Cancer,Metabolism/Metabolic Process
Research Areas (Faceted)
cancer,cell_biology,metabolism
Species
human
Target Sentence
RRM1 is the ribonucleoside-diphosphate reductase large subunit essential for the conversion of ribonucleotides into deoxyribonucleotides [taken from NCBI Entrez Gene (Gene ID: 6240)].
UniGene ID
Hs.445705
UniProt ID (eCommerce)
P23921
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.