human RMI1 shRNA silencing Adenovirus

Name 
Ad-h-RMI1-shRNA
Cat No 
shADV-221280
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human RMI1.

shADV-221280
Ad-h-RMI1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human RMI1 (RecQ mediated genome instability 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
BLAP75; BLM-associated polypeptide, 75 kDa; BLM-associated protein 75 kDa; BLM-associated protein of 75 kDa; C9orf76; FAAP75; homolog of yeast RecQ-mediated genome instability 1 (RMI1); recQ-mediated genome instability protein 1; RMI1, RecQ mediated genome instability 1, homolog
Description (eCommerce)
BLM-associated polypeptide, 75 kDa (BLAP75) is a component of a dissolvasome complex that contains BLM (Bloom syndrome protein) and TopoIII-alpha and functions to dissolve double Holliday junctions and suppress DNA crossover formation in mitotic cells.
Description (Vector)
RMI1 is a component of protein complexes that limit DNA crossover formation via the dissolution of double Holliday junctions (Raynard et al., 2006 (PubMed 16595695)).(supplied by OMIM, Mar 2008)
Gene ID
80010
Gene Name (eCommerce)
RecQ mediated genome instability 1
Gene Name (Vector)
RecQ mediated genome instability 1
Gene Symbol
RMI1
HGNC ID
HGNC:25764
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1140
ORF Size (bp)
1140 bp
Protein Name (eCommerce)
RecQ-mediated genome instability protein 1
RefSeq ID
NM_024945
RefSeq Synonyms
NM_024945, BC064937, BC039999,
Research Areas
DNA Damage/Repair,DNA Replication,Fanconi anemia
Research Areas (Faceted)
genetics,transcription_translation,cell_biology
Species
human
Target Sentence
BLM-associated polypeptide, 75 kDa (BLAP75) is a component of a dissolvasome complex that contains BLM (Bloom syndrome protein) and TopoIII-alpha and functions to dissolve double Holliday junctions and suppress DNA crossover formation in mitotic cells.
UniGene ID
Hs.284137
UniProt ID (eCommerce)
Q9H9A7

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.