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human RBM8A shRNA silencing Adenovirus

Name 
Ad-h-RBM8A-shRNA
Cat No 
shADV-220890
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human RBM8A.

shADV-220890
Ad-h-RBM8A-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human RBM8A (RNA binding motif protein 8A). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
60
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
binder of OVCA1-1; BOV-1; BOV-1A; BOV-1B; BOV-1C; C1DELq21.1; DEL1q21.1; MDS014; RBM8; RBM8B; ribonucleoprotein RBM8; ribonucleoprotein RBM8A; RNA binding motif protein 8B; RNA-binding motif protein 8A; RNA-binding protein 8A; RNA-binding protein Y14; TAR; Y14; ZNRP; ZRNP1
Description (eCommerce)
RBM8a (RNA binding motif protein 8a) contains an RNA recognition motif found in a variety of RNA binding proteins that function in RNA processing. RBM8a appears to play a role in many aspects of mRNA processing such as nonsense-mediated mRNA decay (NMD), mRNA export, and mRNA splicing.
Description (Vector)
RBM8A encodes a protein with a conserved RNA-binding motif. The protein is found predominantly in the nucleus, although it is also present in the cytoplasm. It is preferentially associated with mRNAs produced by splicing, including both nuclear mRNAs and newly exported cytoplasmic mRNAs. It is thought that the protein remains associated with spliced mRNAs as a tag to indicate where introns had been present, thus coupling pre- and post-mRNA splicing events. Previously, it was thought that two genes encode this protein, RBM8A and RBM8B; it is now thought that the RBM8B locus is a pseudogene. Two alternative start codons result in two forms of the protein, and this gene also uses multiple polyadenylation sites.
Gene ID
9939
Gene Name (eCommerce)
RNA binding motif protein 8A
Gene Name (Vector)
RNA binding motif protein 8A
Gene Symbol
RBM8A
HGNC ID
HGNC:9905
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
525
Protein Name (eCommerce)
RNA-binding protein 8A
RefSeq ID
NM_005105
RefSeq Synonyms
NM_005105, BC017088,
Research Areas
Gene Expression,mRNA Binding,mRNA Processing,mRNA Splicing,mRNA Transport,Nuclear Import/Export,RNA Binding,RNA Processing,RNA Transport,Spliceosome,Translational Control,Transport
Research Areas (Faceted)
genetics,transcription_translation,cell_biology
Species
human
Target Sentence
RBM8a (RNA binding motif protein 8a) contains an RNA recognition motif found in a variety of RNA binding proteins that function in RNA processing. RBM8a appears to play a role in many aspects of mRNA processing such as nonsense-mediated mRNA decay (NMD), mRNA export, and mRNA splicing.
UniGene ID
Hs.356873
UniProt ID (eCommerce)
Q9Y5S9

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.