human RANBP3 shRNA silencing Adenovirus

Name
Ad-h-RANBP3-shRNA

Cat No
shADV-220705

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human RANBP3.

shADV-220705

Ad-h-RANBP3-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human RANBP3 (RAN binding protein 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

80

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

epididymis secretory sperm binding protein; ran-binding protein 3; RanBP3

Description (eCommerce)

Ran binding protein 3 (RanBP3) is a Ran (ras-related nuclear protein) binding protein and a component of a nuclear transport complex that functions to export proteins out of the nucleus. RanBP3 binds the nucleocytoplasmic transport receptor, CRM1, and facilitates the export of CRM1 substrates. Recently it has been shown that RanBP3 function is regulated by the Ras/ERK/RSK and PI3K/Akt signaling pathway. This finding has provided a link between nuclear transport, cell signaling, and cell fate.

Description (Vector)

RANBP3 encodes a protein with a RanBD1 domain that is found in both the nucleus and cytoplasm. This protein plays a role in nuclear export as part of a heteromeric complex. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Gene ID

8498

Gene Name (eCommerce)

RAN binding protein 3

Gene Name (Vector)

RAN binding protein 3

Gene Symbol

RANBP3

HGNC ID

HGNC:9850

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1194

ORF Size (bp)

1194 bp

Protein Name (eCommerce)

Ran-binding protein 3

RefSeq ID

NM_003624

RefSeq Synonyms

NM_007322, NM_007320, NM_003624, NM_001300865, BC004349,

Research Areas

Host-Virus Interactions,Signal Transduction,Transport,Wnt Signaling

Research Areas (Faceted)

cell_biology,infectious_disease,signal_transduction

Species

human

Target Sentence

Ran binding protein 3 (RanBP3) is a Ran (ras-related nuclear protein) binding protein and a component of a nuclear transport complex that functions to export proteins out of the nucleus. RanBP3 binds the nucleocytoplasmic transport receptor, CRM1, and facilitates the export of CRM1 substrates. Recently it has been shown that RanBP3 function is regulated by the Ras/ERK/RSK and PI3K/Akt signaling pathway. This finding has provided a link between nuclear transport, cell signaling, and cell fate.

UniGene ID

Hs.531752

UniProt ID (eCommerce)

Q9H6Z4

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.