human LRRC8A Over-expression AAV

Name 
AAV-h-LRRC8A
Cat No 
AAV-214592
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human LRRC8A.

AAV-214592
AAV-h-LRRC8A

Ready-to-use AAV expressing Human LRRC8A (leucine rich repeat containing 8 family member A). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
AGM5; leucine rich repeat containing 8 family member A; leucine-rich repeat-containing protein 8A; LRRC8; SWELL1; swelling protein 1; volume-regulated anion channel subunit LRRC8A
Description (eCommerce)
LRRC8A belongs to the leucine-rich repeat family of proteins, which are involved in diverse biological processes, including cell adhesion, cellular trafficking, and hormone-receptor interactions. LRRC8A is a putative four-pass transmembrane protein that plays a role in B cell development. Defects in the LRRC8A gene cause autosomal dominant non-Bruton type agammaglobulinemia, an immunodeficiency disease resulting from defects in B cell maturation [taken from NCBI Entrez Gene (Gene ID: 56262)].
Description (Vector)
LRRC8A encodes a protein belonging to the leucine-rich repeat family of proteins, which are involved in diverse biological processes, including cell adhesion, cellular trafficking, and hormone-receptor interactions. This family member is a putative four-pass transmembrane protein that plays a role in B cell development. Defects in this gene cause autosomal dominant non-Bruton type agammaglobulinemia, an immunodeficiency disease resulting from defects in B cell maturation. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.
Gene ID
56262
Gene Name (eCommerce)
leucine rich repeat containing 8 VRAC subunit A
Gene Name (Vector)
leucine rich repeat containing 8 family member A
Gene Symbol
LRRC8A
HGNC ID
HGNC:19027
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2433
ORF Size (bp)
2433 bp
Protein Name (eCommerce)
Volume-regulated anion channel subunit LRRC8A
RefSeq ID
NM_019594
RefSeq Synonyms
NM_019594, NM_001127245, NM_001127244, BC051322,
Research Areas
Immunology
Research Areas (Faceted)
immunology
Species
human
Target Sentence
LRRC8A belongs to the leucine-rich repeat family of proteins, which are involved in diverse biological processes, including cell adhesion, cellular trafficking, and hormone-receptor interactions. LRRC8A is a putative four-pass transmembrane protein that plays a role in B cell development. Defects in the LRRC8A gene cause autosomal dominant non-Bruton type agammaglobulinemia, an immunodeficiency disease resulting from defects in B cell maturation [taken from NCBI Entrez Gene (Gene ID: 56262)].
UniGene ID
Hs.643600
UniProt ID (eCommerce)
Q8IWT6

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.