human PVRIG shRNA silencing Adenovirus

Name 
Ad-h-PVRIG-shRNA
Cat No 
shADV-220416
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human PVRIG.

shADV-220416
Ad-h-PVRIG-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human PVRIG (poliovirus receptor related immunoglobulin domain containing). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
C7orf15;CD112 receptor;CD112R;nectin-2 receptor;poliovirus receptor related immunoglobulin domain containing;poliovirus receptor-related immunoglobulin domain-containing protein;transmembrane protein PVRIG
Description (eCommerce)
PVRIG, aka CD112R, is a cell surface receptor for NECTIN2 that acts as a coinhibitory receptor suppressing T-cell receptor-mediated signals. Following interaction with NECTIN2, PVRIG inhibits T-cell proliferation. PVRIG also competes with CD226 for NECTIN2-binding. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q6DKI7].
Gene ID
79037
Gene Name (eCommerce)
PVR related immunoglobulin domain containing
Gene Name (Vector)
poliovirus receptor related immunoglobulin domain containing
Gene Symbol
PVRIG
HGNC ID
HGNC:32190
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
981
ORF Size (bp)
981 bp
Protein Name (eCommerce)
Transmembrane protein PVRIG
RefSeq ID
NM_024070
RefSeq Synonyms
NM_024070, BC107873, BC073861, BC001129,
Research Areas
Immunology,Immuno-Oncology
Research Areas (Faceted)
immunology,immuno_oncology
Species
human
Target Sentence
PVRIG, aka CD112R, is a cell surface receptor for NECTIN2 that acts as a coinhibitory receptor suppressing T-cell receptor-mediated signals. Following interaction with NECTIN2, PVRIG inhibits T-cell proliferation. PVRIG also competes with CD226 for NECTIN2-binding. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q6DKI7].
UniGene ID
Hs.521075
UniProt ID (eCommerce)
Q6DKI7

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.