human PVRIG Over-expression AAV

Name 
AAV-h-PVRIG
Cat No 
AAV-220416
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human PVRIG.

AAV-220416
AAV-h-PVRIG

Ready-to-use AAV expressing Human PVRIG (poliovirus receptor related immunoglobulin domain containing). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
C7orf15;CD112 receptor;CD112R;nectin-2 receptor;poliovirus receptor related immunoglobulin domain containing;poliovirus receptor-related immunoglobulin domain-containing protein;transmembrane protein PVRIG
Description (eCommerce)
PVRIG, aka CD112R, is a cell surface receptor for NECTIN2 that acts as a coinhibitory receptor suppressing T-cell receptor-mediated signals. Following interaction with NECTIN2, PVRIG inhibits T-cell proliferation. PVRIG also competes with CD226 for NECTIN2-binding. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q6DKI7].
Gene ID
79037
Gene Name (eCommerce)
PVR related immunoglobulin domain containing
Gene Name (Vector)
poliovirus receptor related immunoglobulin domain containing
Gene Symbol
PVRIG
HGNC ID
HGNC:32190
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
981
ORF Size (bp)
981 bp
Protein Name (eCommerce)
Transmembrane protein PVRIG
RefSeq ID
NM_024070
RefSeq Synonyms
NM_024070, BC107873, BC073861, BC001129,
Research Areas
Immunology,Immuno-Oncology
Research Areas (Faceted)
immunology,immuno_oncology
Species
human
Target Sentence
PVRIG, aka CD112R, is a cell surface receptor for NECTIN2 that acts as a coinhibitory receptor suppressing T-cell receptor-mediated signals. Following interaction with NECTIN2, PVRIG inhibits T-cell proliferation. PVRIG also competes with CD226 for NECTIN2-binding. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q6DKI7].
UniGene ID
Hs.521075
UniProt ID (eCommerce)
Q6DKI7

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.