human PSMB8 shRNA silencing Adenovirus

ALDD; D6S216; D6S216E; JMP; LMP7; low molecular mass protein 7; low molecular weight protein 7; macropain subunit C13; multicatalytic endopeptidase complex subunit C13; NKJO; PRAAS1; protease component C13; proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7); proteasome catalytic subunit 3i; proteasome component C13; proteasome subunit beta 5i; proteasome subunit beta type-8; Proteasome subunit beta-5i; proteasome subunit Y2; proteasome-related gene 7; PSMB5i; really interesting new gene 10 protein; RING10

Proteasomes are distributed throughout eukaryotic cells and cleave peptides in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The gene PSMB8 (aka LMP7) encodes a member of the proteasome B-type family, proteasome subunit beta type-8, that is a 20S core beta subunit. Expression of PSMB8/LMP7 is induced by gamma interferon and the PSMB8 gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Nakajo syndrome, an autosomal recessive autoinflammatory disorder, is caused by mutations to PSMB8 [taken from NCBI Entrez Gene (Gene ID: 5696) and UniProtKB (Entry: P28062)].

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit.

5696

proteasome subunit beta 8

proteasome subunit beta 8

PSMB8

HGNC:9545

9606.0

819

Proteasome subunit beta type-8

NM_004159

NM_148919, NM_004159, BC001114,

Antigen Processing and Presentation,Apoptosis,B-cell Receptor Signaling,Cell Cycle,Complexome,DNA Damage/Repair,Gene Expression,Hedgehog Signaling,Host-Virus Interactions,IFN Signaling,Immunology,Interleukin Signaling,JAK-STAT Signaling,NF-kB Signaling,Notch Signaling,Proteasome,RNA Processing,Signal Transduction,T-cell Receptor Signaling,TGF-beta Signaling,TNF Signaling,Toll-like Receptor Signaling,Wnt Signaling

signal_transduction,immunology,cell_biology,signal_transduction,immunology,cell_biology,cell_cycle,genetics,transcription_translation,signal_transduction,developmental_biology,infectious_disease,immunology,signal_transduction,signal_transduction,developmental_biology,cell_biology,genetics,transcription_translation,signal_transduction,immunology,signal_transduction,developmental_biology

human

Proteasomes are distributed throughout eukaryotic cells and cleave peptides in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The gene PSMB8 (aka LMP7) encodes a member of the proteasome B-type family, proteasome subunit beta type-8, that is a 20S core beta subunit. Expression of PSMB8/LMP7 is induced by gamma interferon and the PSMB8 gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Nakajo syndrome, an autosomal recessive autoinflammatory disorder, is caused by mutations to PSMB8 [taken from NCBI Entrez Gene (Gene ID: 5696) and UniProtKB (Entry: P28062)].

Hs.180062

P28062