human PSMA6 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human PSMA6.
shADV-220106
Ad-h-PSMA6-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human PSMA6 (proteasome subunit alpha 6). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
27 kDa prosomal protein; IOTA; macropain iota chain; macropain subunit iota; multicatalytic endopeptidase complex iota chain; p27K; PROS27; PROS-27; prosomal P27K protein; proteasome (prosome, macropain) subunit, alpha type, 6; proteasome iota chain; proteasome subunit alpha type-6; proteasome subunit iota; testicular secretory protein Li 44
Description (eCommerce)
Proteasome subunit alpha type-6 (PSMA6) is a component of the proteasome. The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P60900].
Description (Vector)
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. A pseudogene has been identified on the Y chromosome.
Gene ID
5687
Gene Name (eCommerce)
proteasome subunit alpha 6
Gene Name (Vector)
proteasome subunit alpha 6
Gene Symbol
PSMA6
HGNC ID
HGNC:9535
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
741
Protein Name (eCommerce)
Proteasome subunit alpha type-6
RefSeq ID
NM_002791
RefSeq Synonyms
NM_002791, NM_001282234, NM_001282233, NM_001282232, BC070137, BC023659, BC022354, BC017882, BC002979,
Research Areas
Antigen Processing and Presentation,Apoptosis,B-cell Receptor Signaling,Cell Cycle,Complexome,DNA Damage/Repair,Gene Expression,Hedgehog Signaling,Host-Virus Interactions,Immunology,Interleukin Signaling,JAK-STAT Signaling,Mitochondrion,NF-kB Signaling,Notch Signaling,Proteasome,RNA Binding,RNA Processing,Signal Transduction,T-cell Receptor Signaling,TGF-beta Signaling,TNF Signaling,Toll-like Receptor Signaling,Ubiquitination,Wnt Signaling
Research Areas (Faceted)
cell_biology,cell_cycle,developmental_biology,genetics,immunology,infectious_disease,signal_transduction,transcription_translation
Species
human
Target Sentence
Proteasome subunit alpha type-6 (PSMA6) is a component of the proteasome. The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P60900].
UniGene ID
Hs.446260
UniProt ID (eCommerce)
P60900
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.