human PRMT1 shRNA silencing Adenovirus

Name 
Ad-h-PRMT1-shRNA
Cat No 
shADV-219898
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human PRMT1.

shADV-219898
Ad-h-PRMT1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human PRMT1 (protein arginine methyltransferase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
ANM1; HCP1; heterogeneous nuclear ribonucleoprotein methyltransferase 1-like 2; histone-arginine N-methyltransferase PRMT1; HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2; HRMT1L2; interferon receptor 1-bound protein 4; IR1B4; protein arginine N-methyltransferase 1
Description (eCommerce)
Protein arginine methylation is a form of post-translational modification that is catalyzed by protein arginine methyltransferases (PRMTs). Substrates of PRMT1 include RNA binding proteins, histones, and the DNA damage response proteins MRE11 and 53BP1. These interactions suggest a role for PRMT1 in the regulation of RNA metabolism, transcription and the DNA damage response.
Description (Vector)
PRMT1 encodes a member of the protein arginine N-methyltransferase (PRMT) family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal guanidino nitrogen atoms. The encoded protein is a type I PRMT and is responsible for the majority of cellular arginine methylation activity. Increased expression of this gene may play a role in many types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5.
Gene ID
3276
Gene Name (eCommerce)
protein arginine methyltransferase 1
Gene Name (Vector)
protein arginine methyltransferase 1
Gene Symbol
PRMT1
HGNC ID
HGNC:5187
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1032
ORF Size (bp)
1032 bp
Protein Name (eCommerce)
Protein arginine N-methyltransferase 1
RefSeq ID
NM_001536
RefSeq Synonyms
NM_198318, NM_001536, NM_001207042, BC109283, BC109282,
Research Areas
Cell Cycle,Histone Modification,IFN Signaling,Metabolism/Metabolic Process,Methyltransferase,mRNA Processing,Neurobiology,Neurodevelopment,RNA Processing,Signal Transduction
Research Areas (Faceted)
cell_biology,cell_cycle,developmental_biology,genetics,transcription_translation,immunology,metabolism,neurobiology,signal_transduction
Species
human
Target Sentence
Protein arginine methylation is a form of post-translational modification that is catalyzed by protein arginine methyltransferases (PRMTs). Substrates of PRMT1 include RNA binding proteins, histones, and the DNA damage response proteins MRE11 and 53BP1. These interactions suggest a role for PRMT1 in the regulation of RNA metabolism, transcription and the DNA damage response.
UniGene ID
Hs.20521
UniProt ID (eCommerce)
Q99873

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.