human PPP2R3B shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human PPP2R3B.
shADV-219657
Ad-h-PPP2R3B-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human PPP2R3B (protein phosphatase 2 regulatory subunit B”beta). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
NYREN8; NY-REN-8 antigen; PP2A subunit B isoform PR48; PP2A, subunit B, PR48 isoform; PPP2R3L; PPP2R3LY; PR48; PR70; protein phosphatase 2 (formerly 2A), regulatory subunit B'', beta; protein phosphatase 2, regulatory subunit B'', beta; Protein phosphatase 2A 48 kDa regulatory subunit; serine/threonine protein phosphatase 2A, 48kDa regulatory subunit B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta
Description (eCommerce)
PP2A is a major serine/threonine phosphatase that is implicated in the negative control of cell cycle progression. It is a trimeric holoenzyme that is comprised of a catalytic, structural, and regulatory subunit. PPP2R3B is a regulatory subunit of PP2A. The regulatory subunits of PP2A are grouped into 3 families: B/PR55, B’/PR61, and B’’/PR72. PPP2R3B encodes a 48 kDa B’’ regulatory subunit. PPP2R3B and PP2A, in association with Cdc6, are implicated in cell cycle control via phosphatase activity targeted at DNA replication machinery. serine/threonine-protein phosphatase 2A 48 kDa regulatory subunit B, PP2A subunit B PR48 isoform, PPP2R3L, PR48, NY-REN-8, PPP2R3LY.
Description (Vector)
Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the beta subfamily of regulatory subunit B''.
Gene ID
28227
Gene Name (eCommerce)
protein phosphatase 2 regulatory subunit B''beta
Gene Name (Vector)
protein phosphatase 2 regulatory subunit B''beta
Gene Symbol
PPP2R3B
HGNC ID
HGNC:13417
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1728
ORF Size (bp)
1728 bp
Protein Name (eCommerce)
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta
RefSeq ID
NM_013239
RefSeq Synonyms
NM_013239, BC063429, BC011180, BC009032,
Research Areas
Cell Cycle,DNA Damage/Repair,DNA Replication,Kinase/Phosphatase,Metabolism/Metabolic Process,Neurobiology,PI3K/Akt Signaling,Signal Transduction,Wnt Signaling
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,metabolism,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
PP2A is a major serine/threonine phosphatase that is implicated in the negative control of cell cycle progression. It is a trimeric holoenzyme that is comprised of a catalytic, structural, and regulatory subunit. PPP2R3B is a regulatory subunit of PP2A. The regulatory subunits of PP2A are grouped into 3 families: B/PR55, B’/PR61, and B’’/PR72. PPP2R3B encodes a 48 kDa B’’ regulatory subunit. PPP2R3B and PP2A, in association with Cdc6, are implicated in cell cycle control via phosphatase activity targeted at DNA replication machinery. serine/threonine-protein phosphatase 2A 48 kDa regulatory subunit B, PP2A subunit B PR48 isoform, PPP2R3L, PR48, NY-REN-8, PPP2R3LY.
UniGene ID
Hs.124942
UniProt ID (eCommerce)
Q9Y5P8
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.