human PPM1F shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human PPM1F.
shADV-219580
Ad-h-PPM1F-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human PPM1F (protein phosphatase, Mg2+/Mn2+ dependent 1F). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CAMKP; CaMKPase; FEM-2; hFEM-2; POPX2
Description (Vector)
PPM1F is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined.
Gene ID
9647
Gene Name (Vector)
protein phosphatase, Mg2+/Mn2+ dependent 1F
Gene Symbol
PPM1F
HGNC ID
HGNC:19388
ORF Size (aa)
1362
ORF Size (bp)
1362 bp
RefSeq ID
NM_014634
RefSeq Synonyms
NM_014634, BC105599, BC071989,
Species
human
UniGene ID
Hs.112728
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.