human PLN shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human PLN.
shADV-219217
Ad-h-PLN-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human PLN (phospholamban). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CMD1P; CMH18; PLB
Description (Vector)
PLN is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure.
Gene ID
5350
Gene Name (Vector)
phospholamban
Gene Symbol
PLN
HGNC ID
HGNC:9080
ORF Size (aa)
159
RefSeq ID
NM_002667
RefSeq Synonyms
NM_002667, BC005269,
Species
human
UniGene ID
Hs.170839
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.