human PKN1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human PKN1.
shADV-219040
Ad-h-PKN1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human PKN1 (protein kinase N1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
DBK; PAK-1; PAK1; PKN; PKN-ALPHA; PRK1; PRKCL1
Description (Vector)
PKN1 belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Gene ID
5585
Gene Name (Vector)
protein kinase N1
Gene Symbol
PKN1
HGNC ID
HGNC:9405
ORF Size (aa)
1812
ORF Size (bp)
1812 bp
RefSeq ID
NM_002741
RefSeq Synonyms
NM_213560, NM_002741, BC094766, BC040061,
Species
human
UniGene ID
Hs.466044
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.