human PINX1 shRNA silencing Adenovirus

Name 
Ad-h-PINX1-shRNA
Cat No 
shADV-218976
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human PINX1.

shADV-218976
Ad-h-PINX1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human PINX1 (PIN2/TERF1 interacting, telomerase inhibitor 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
67-11-3 protein; Gno1; hepatocellular carcinoma-related putative tumor suppressor; liver-related putative tumor suppressor; LPTL; LPTS; PIN2/TERF1-interacting telomerase inhibitor 1; PIN2-interacting protein 1; pin2-interacting protein X1; protein 67-11-3; Pxr1; TRF1-interacting protein 1
Description (eCommerce)
PINX1 is a microtubule-binding protein essential for faithful chromosome segregation. PINX1 mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. It inhibits telomerase activity and may inhibit cell proliferation and act as tumor suppressor [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q96BK5].
Gene ID
54984
Gene Name (eCommerce)
PIN2 (TERF1) interacting telomerase inhibitor 1
Gene Name (Vector)
PIN2/TERF1 interacting, telomerase inhibitor 1
Gene Symbol
PINX1
HGNC ID
HGNC:30046
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
987
ORF Size (bp)
987 bp
Protein Name (eCommerce)
PIN2/TERF1-interacting telomerase inhibitor 1
RefSeq ID
NM_017884
RefSeq Synonyms
NM_017884, NM_001284356, BC093762, BC015479,
Research Areas
Cancer,Cell Cycle,Cell Division,Mitochondrion,RNA Binding,Telomeric Maintenance,Tumor Suppressors/Oncoproteins
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,genetics
Species
human
Target Sentence
PINX1 is a microtubule-binding protein essential for faithful chromosome segregation. PINX1 mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. It inhibits telomerase activity and may inhibit cell proliferation and act as tumor suppressor [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q96BK5].
UniGene ID
Hs.583894
UniProt ID (eCommerce)
Q96BK5

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.