human PFKFB2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human PFKFB2.
shADV-218669
Ad-h-PFKFB2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human PFKFB2 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
6PF-2-K/Fru-2,6-P2ase 2; 6PF-2-K/Fru-2,6-P2ASE heart-type isozyme; 6-phosphofructo-2-kinase; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2; fructose-2,6-bisphosphatase, cardiac isozyme; PFK/FBPase 2; PFK-2/FBPase-2; PFKFB, cardiac
Description (eCommerce)
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (PFKFB2) is involved in the synthesis and degradation of fructose 2,6-bisphosphate [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O60825].
Description (Vector)
PFKFB2 is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene.
Gene ID
5208
Gene Name (eCommerce)
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
Gene Name (Vector)
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
Gene Symbol
PFKFB2
HGNC ID
HGNC:8873
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1518
ORF Size (bp)
1518 bp
Protein Name (eCommerce)
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2
RefSeq ID
NM_006212
RefSeq Synonyms
NM_006212, NM_001018053, BC112105, BC112103, BC075076, BC075075, BC069600, BC069586, BC069583, BC069385, BC069350,
Research Areas
HIF-1 Signaling,Metabolism/Metabolic Process,Signal Transduction
Research Areas (Faceted)
cell_biology,metabolism,signal_transduction
Species
human
Target Sentence
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (PFKFB2) is involved in the synthesis and degradation of fructose 2,6-bisphosphate [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O60825].
UniGene ID
Hs.282702
UniProt ID (eCommerce)
O60825
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.