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human PDE4B shRNA silencing Adenovirus

Name 
Ad-h-PDE4B-shRNA
Cat No 
shADV-218476
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human PDE4B.

shADV-218476
Ad-h-PDE4B-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human PDE4B (phosphodiesterase 4B). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
DPDE4; PDEIVB
Description (Vector)
PDE4B is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. PDE4B encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Gene ID
5142
Gene Name (Vector)
phosphodiesterase 4B
Gene Symbol
PDE4B
HGNC ID
HGNC:8781
ORF Size (aa)
2211
ORF Size (bp)
2211 bp
RefSeq ID
NM_002600
RefSeq Synonyms
NM_002600, NM_001297442, NM_001297441, NM_001297440, NM_001037341, NM_001037340, NM_001037339, BC105040, BC101480,
Species
human
UniGene ID
Hs.198072

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.