human PCM1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human PCM1.
shADV-218385
Ad-h-PCM1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human PCM1 (pericentriolar material 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
hPCM-1; PCM-1; pericentriolar material 1 protein; pericentriolar material 1, PCM1; PTC4; RET/PCM-1
Description (eCommerce)
PCM1 (pericentriolar material protein 1) is involved in centrosomal trafficking and may function to transport centrosomal proteins to the centrosome along microtubules. Knockdown of PCM1 results in defects in centrosomal assembly, cell cycle arrest in G0 or G1, and activation of the p38-dependent stress pathway and the p53-dependent cell cycle checkpoint. PCM1 is implicated in the susceptibility to schizophrenia.
Description (Vector)
PCM1 is a component of centriolar satellites, which are electron dense granules scattered around centrosomes. Inhibition studies show that this protein is essential for the correct localization of several centrosomal proteins, and for anchoring microtubules to the centrosome. Chromosomal aberrations involving this gene are associated with papillary thyroid carcinomas and a variety of hematological malignancies, including atypical chronic myeloid leukemia and T-cell lymphoma.
Gene ID
5108
Gene Name (eCommerce)
pericentriolar material 1
Gene Name (Vector)
pericentriolar material 1
Gene Symbol
PCM1
HGNC ID
HGNC:8727
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
6051
ORF Size (bp)
6051 bp
Protein Name (eCommerce)
Pericentriolar material 1 protein
RefSeq ID
NM_006197
RefSeq Synonyms
NM_006197, NM_001315508, NM_001315507, BC140946, BC133052, BC000453,
Research Areas
Cancer,Cell Cycle,Cytoskeleton,Neurobiology,Neurodevelopment,Neurogenesis
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,developmental_biology,genetics,neurobiology
Species
human
Target Sentence
PCM1 (pericentriolar material protein 1) is involved in centrosomal trafficking and may function to transport centrosomal proteins to the centrosome along microtubules. Knockdown of PCM1 results in defects in centrosomal assembly, cell cycle arrest in G0 or G1, and activation of the p38-dependent stress pathway and the p53-dependent cell cycle checkpoint. PCM1 is implicated in the susceptibility to schizophrenia.
UniGene ID
Hs.491148
UniProt ID (eCommerce)
Q15154
Recently Viewed Products
Ad-CMV-iCre
Cat No: 1045
Ad-CMV-Caspase 9 (DN)
Cat No: 1044
Ad-CMV-Rb
Cat No: 1043
Ad-CMV-p27
Cat No: 1042
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.