human PAX3 shRNA silencing Adenovirus

Name
Ad-h-PAX3-shRNA

Cat No
shADV-218272

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human PAX3.

shADV-218272

Ad-h-PAX3-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human PAX3 (paired box 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

CDHS; HUP2; WS1; WS3

Description (Vector)

PAX3 is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2;13)(q35;q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma. Alternative splicing results in transcripts encoding isoforms with different C-termini.

Gene ID

5077

Gene Name (Vector)

paired box 3

Gene Symbol

PAX3

HGNC ID

HGNC:8617

ORF Size (aa)

1455

ORF Size (bp)

1455 bp

RefSeq ID

NM_000438

RefSeq Synonyms

NM_181461, NM_181460, NM_181459, NM_181458, NM_181457, NM_013942, NM_001127366, NM_000438, BC114363, BC101302, BC101301, BC101300, BC101299,

Species

human

UniGene ID

Hs.42146

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.