human PPP2R5C Over-expression AAV

B' alpha regulatory subunit; B56G; B56gamma; PP2A B subunit isoform B56-gamma; PP2A B subunit isoform B'-gamma; PP2A B subunit isoform PR61-gamma; PP2A B subunit isoform R5-gamma; PR61G; protein phosphatase 2 regulatory subunit B', gamma; protein phosphatase 2, regulatory subunit B (B56), gamma isoform; protein phosphatase 2, regulatory subunit B', gamma isoform; renal carcinoma antigen NY-REN-29; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform

Protein phosphatase 2, regulatory subunit B', gamma (PPP2R5C) is a regulatory subunit of the PP2A phosphatase. The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q13362].

The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified.

5527

protein phosphatase 2 regulatory subunit B'gamma

protein phosphatase 2 regulatory subunit B', gamma

PPP2R5C

HGNC:9311

9606.0

1155

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform

NM_002719

NM_178587, NM_178586, NM_002719, NM_001161726, NM_001161725, BC016183,

Apoptosis,Cell Cycle,DNA Damage/Repair,Immunology,Kinase/Phosphatase,Meiosis,Metabolism/Metabolic Process,Neurobiology,PI3K/Akt Signaling,Signal Transduction,Wnt Signaling

signal_transduction,cell_biology,cell_cycle,genetics,transcription_translation,immunology,cell_biology,cell_cycle,metabolism,neurobiology,signal_transduction,developmental_biology

human

Protein phosphatase 2, regulatory subunit B', gamma (PPP2R5C) is a regulatory subunit of the PP2A phosphatase. The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q13362].

Hs.710260

Q13362