human NDUFB6 shRNA silencing Adenovirus

Name 
Ad-h-NDUFB6-shRNA
Cat No 
shADV-216510
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human NDUFB6.

shADV-216510
Ad-h-NDUFB6-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human NDUFB6 (NADH:ubiquinone oxidoreductase subunit B6). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
B17; CI; CI-B17; complex I, mitochondrial respiratory chain, B17 subunit; complex I-B17; NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa; NADH dehydrogenase ubiquinone 1 beta subcomplex subunit 6; NADH-ubiquinone oxidoreductase B17 subunit; NADH-ubiquinone oxidoreductase beta subunit, 6
Description (eCommerce)
NDUFB6 is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. NDUFB6 has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone [taken from NCBI Entrez Gene (Gene ID: 4712)].
Description (Vector)
NDUFB6 is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Alternative splicing occurs at this locus and three transcript variants encoding distinct isoforms have been identified.
Gene ID
4712
Gene Name (eCommerce)
NADH:ubiquinone oxidoreductase subunit B6
Gene Name (Vector)
NADH:ubiquinone oxidoreductase subunit B6
Gene Symbol
NDUFB6
HGNC ID
HGNC:7701
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
387
Protein Name (eCommerce)
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6
RefSeq ID
NM_182739
RefSeq Synonyms
NM_182739, NM_002493, NM_001199987, BC029247, BC009801,
Research Areas
Alzheimer's Disease,Huntington's Disease,Metabolism/Metabolic Process,Mitochondrion,Neurobiology,Neurodegeneration,Parkinson's Disease
Research Areas (Faceted)
neurobiology,metabolism,cell_biology
Species
human
Target Sentence
NDUFB6 is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. NDUFB6 has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone [taken from NCBI Entrez Gene (Gene ID: 4712)].
UniGene ID
Hs.493668
UniProt ID (eCommerce)
O95139

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.