human HYAL3 shRNA silencing Adenovirus

Name 
Ad-h-HYAL3-shRNA
Cat No 
shADV-216347
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human HYAL3.

shADV-216347
Ad-h-HYAL3-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human HYAL3 (hyaluronoglucosaminidase 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
HYAL-3; LUCA-3; LUCA3
Description (Vector)
HYAL3 encodes a member of the hyaluronidase family. Hyaluronidases are endoglycosidase enzymes that degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. The regulated turnover of hyaluronan plays a critical role in many biological processes including cell proliferation, migration and differentiation. The encoded protein may also play an important role in sperm function. HYAL3 is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression, and the expression of specific transcript variants may be indicative of tumor status. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and some isoforms may lack hyaluronidase activity. HYAL3 overlaps and is on the same strand as N-acetyltransferase 6 (GCN5-related), and some transcripts of each gene share a portion of the first exon.
Gene ID
8372
Gene Name (Vector)
hyaluronoglucosaminidase 3
Gene Symbol
HYAL3
HGNC ID
HGNC:5322
ORF Size (aa)
1254
ORF Size (bp)
1254 bp
RefSeq ID
NM_003549
RefSeq Synonyms
NM_003549, NM_001200032, NM_001200031, NM_001200030, NM_001200029, BC012892, BC005896,
Species
human
UniGene ID
Hs.129910

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.