human MYST1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human KAT8.
shADV-216249
Ad-h-MYST1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human KAT8 (lysine acetyltransferase 8). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
histone acetyltransferase KAT8; histone acetyltransferase MYST1; hMOF; K(lysine) acetyltransferase 8; Lysine acetyltransferase 8; MOF; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1; MYST histone acetyltransferase 1; MYST1; MYST-1; ortholog of Drosophila males absent on the first (MOF); probable histone acetyltransferase MYST1; ZC2HC8
Description (eCommerce)
MOF is a member of the MYST family of histone acetyltransferases (HAT). MOF has been shown to be required for histone H4 lysine K16-specific acetylation. MOF interacts with ATM (ataxia-telangiectasia-mutated) and may participate in the activation of ATM in response to DNA damage.
Description (Vector)
KAT8 encodes a member of the MYST histone acetylase protein family. The encoded protein has a characteristic MYST domain containing an acetyl-CoA-binding site, a chromodomain typical of proteins which bind histones, and a C2HC-type zinc finger. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
84148
Gene Name (eCommerce)
lysine acetyltransferase 8
Gene Name (Vector)
lysine acetyltransferase 8
Gene Symbol
KAT8
HGNC ID
HGNC:17933
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1404
ORF Size (bp)
1404 bp
Protein Name (eCommerce)
Histone acetyltransferase KAT8
RefSeq ID
NM_032188
RefSeq Synonyms
NM_182958, NM_032188, BC037773,
Research Areas
Acyltransferase,Cell Cycle,Chromatin Remodeling,Histone Modification,p53 Signaling,Signal Transduction,Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
signal_transduction,cell_biology,cell_cycle,transcription_translation,genetics,signal_transduction,genetics,transcription_translation,cell_biology
Species
human
Target Sentence
MOF is a member of the MYST family of histone acetyltransferases (HAT). MOF has been shown to be required for histone H4 lysine K16-specific acetylation. MOF interacts with ATM (ataxia-telangiectasia-mutated) and may participate in the activation of ATM in response to DNA damage.
UniGene ID
Hs.533803
UniProt ID (eCommerce)
Q9H7Z6
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.