human MYST1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human KAT8.
shAAV-216249
AAV-h-MYST1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human KAT8 (lysine acetyltransferase 8). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
histone acetyltransferase KAT8; histone acetyltransferase MYST1; hMOF; K(lysine) acetyltransferase 8; Lysine acetyltransferase 8; MOF; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1; MYST histone acetyltransferase 1; MYST1; MYST-1; ortholog of Drosophila males absent on the first (MOF); probable histone acetyltransferase MYST1; ZC2HC8
Description (eCommerce)
MOF is a member of the MYST family of histone acetyltransferases (HAT). MOF has been shown to be required for histone H4 lysine K16-specific acetylation. MOF interacts with ATM (ataxia-telangiectasia-mutated) and may participate in the activation of ATM in response to DNA damage.
Description (Vector)
KAT8 encodes a member of the MYST histone acetylase protein family. The encoded protein has a characteristic MYST domain containing an acetyl-CoA-binding site, a chromodomain typical of proteins which bind histones, and a C2HC-type zinc finger. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
84148
Gene Name (eCommerce)
lysine acetyltransferase 8
Gene Name (Vector)
lysine acetyltransferase 8
Gene Symbol
KAT8
HGNC ID
HGNC:17933
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1404
ORF Size (bp)
1404 bp
Protein Name (eCommerce)
Histone acetyltransferase KAT8
RefSeq ID
NM_032188
RefSeq Synonyms
NM_182958, NM_032188, BC037773,
Research Areas
Acyltransferase,Cell Cycle,Chromatin Remodeling,Histone Modification,p53 Signaling,Signal Transduction,Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
signal_transduction,cell_biology,cell_cycle,transcription_translation,genetics,signal_transduction,genetics,transcription_translation,cell_biology
Species
human
Target Sentence
MOF is a member of the MYST family of histone acetyltransferases (HAT). MOF has been shown to be required for histone H4 lysine K16-specific acetylation. MOF interacts with ATM (ataxia-telangiectasia-mutated) and may participate in the activation of ATM in response to DNA damage.
UniGene ID
Hs.533803
UniProt ID (eCommerce)
Q9H7Z6
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.