human MTPN Over-expression AAV

Name 
AAV-h-MTPN
Cat No 
AAV-214106
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human MTPN.

AAV-214106
AAV-h-MTPN

Ready-to-use AAV expressing Human MTPN (myotrophin). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
GCDP; granule cell differentiation protein; myotrophin; protein V-1; V-1
Description (eCommerce)
MTPN promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity (By similarity). MTPN plays a role in the regulation of the growth of actin filaments. MTPN inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P58546].
Description (Vector)
The transcript produced from this gene is bi-cistronic and can encode both myotrophin and leucine zipper protein 6. The myotrophin protein is associated with cardiac hypertrophy, where it is involved in the conversion of NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers. This protein also has a potential function in cerebellar morphogenesis, and it may be involved in the differentiation of cerebellar neurons, particularly of granule cells. A cryptic ORF at the 3' end of this transcript uses a novel internal ribosome entry site and a non-AUG translation initiation codon to produce leucine zipper protein 6, a 6.4 kDa tumor antigen that is associated with myeloproliferative disease.
Gene ID
136319
Gene Name (eCommerce)
myotrophin
Gene Name (Vector)
myotrophin
Gene Symbol
MTPN
HGNC ID
HGNC:15667
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
357
Protein Name (eCommerce)
Myotrophin
RefSeq ID
NM_145808
RefSeq Synonyms
NM_145808, BC028093,
Research Areas
Cardiac Hypertrophy,Cardiology,Cardiovascular,Immunology,Neurobiology,Neurodevelopment,Translational Control
Research Areas (Faceted)
cardiovascular,cell_biology,developmental_biology,immunology,neurobiology,transcription_translation
Species
human
Target Sentence
MTPN promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity (By similarity). MTPN plays a role in the regulation of the growth of actin filaments. MTPN inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P58546].
UniGene ID
Hs.602015
UniProt ID (eCommerce)
P58546

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.