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human MTPN shRNA silencing Adenovirus

Name 
Ad-h-MTPN-shRNA
Cat No 
shADV-214106
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human MTPN.

shADV-214106
Ad-h-MTPN-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human MTPN (myotrophin). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
98
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
GCDP; granule cell differentiation protein; myotrophin; protein V-1; V-1
Description (eCommerce)
MTPN promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity (By similarity). MTPN plays a role in the regulation of the growth of actin filaments. MTPN inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P58546].
Description (Vector)
The transcript produced from this gene is bi-cistronic and can encode both myotrophin and leucine zipper protein 6. The myotrophin protein is associated with cardiac hypertrophy, where it is involved in the conversion of NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers. This protein also has a potential function in cerebellar morphogenesis, and it may be involved in the differentiation of cerebellar neurons, particularly of granule cells. A cryptic ORF at the 3' end of this transcript uses a novel internal ribosome entry site and a non-AUG translation initiation codon to produce leucine zipper protein 6, a 6.4 kDa tumor antigen that is associated with myeloproliferative disease.
Gene ID
136319
Gene Name (eCommerce)
myotrophin
Gene Name (Vector)
myotrophin
Gene Symbol
MTPN
HGNC ID
HGNC:15667
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
357
Protein Name (eCommerce)
Myotrophin
RefSeq ID
NM_145808
RefSeq Synonyms
NM_145808, BC028093,
Research Areas
Cardiac Hypertrophy,Cardiology,Cardiovascular,Immunology,Neurobiology,Neurodevelopment,Translational Control
Research Areas (Faceted)
cardiovascular,cell_biology,developmental_biology,immunology,neurobiology,transcription_translation
Species
human
Target Sentence
MTPN promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity (By similarity). MTPN plays a role in the regulation of the growth of actin filaments. MTPN inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P58546].
UniGene ID
Hs.602015
UniProt ID (eCommerce)
P58546

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.