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human MUC1 shRNA silencing Adenovirus

Name 
Ad-h-MUC1-shRNA
Cat No 
shADV-216067
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human MUC1.

shADV-216067
Ad-h-MUC1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human MUC1 (mucin 1, cell surface associated). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
ADMCKD; ADMCKD1; CA 15-3; CD227; EMA; H23AG; KL-6; MAM6; MCD; MCKD; MCKD1; MUC-1; MUC-1/SEC; MUC-1/X; MUC1/ZD; PEM; PEMT; PUM
Description (Vector)
MUC1 encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. MUC1 is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.
Gene ID
4582
Gene Name (Vector)
mucin 1, cell surface associated
Gene Symbol
MUC1
HGNC ID
HGNC:7508
ORF Size (aa)
768
RefSeq ID
NM_002456
RefSeq Synonyms
NM_002456, NM_001204297, NM_001204296, NM_001204295, NM_001204294, NM_001204293, NM_001204292, NM_001204291, NM_001204290, NM_001204289, NM_001204288, NM_001204287, NM_001204286, NM_001204285, NM_001044393, NM_001044392, NM_001044391, NM_001044390, NM_001018017, NM_001018016, BC120975, BC120974,
Species
human
UniGene ID
Hs.89603

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.