human MRPS18A shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human MRPS18A.
shADV-215853
Ad-h-MRPS18A-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human MRPS18A (mitochondrial ribosomal protein S18A). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
HumanS18b; MRP-S18-3; MRPS18-3; S18bmt
Description (Vector)
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S18P family. The encoded protein is one of three that has significant sequence similarity to bacterial S18 proteins. The primary sequences of the three human mitochondrial S18 proteins are no more closely related to each other than they are to the prokaryotic S18 proteins. A pseudogene corresponding to this gene is found on chromosome 3p. Alternative splicing results in multiple transcript variants.
Gene ID
55168
Gene Name (Vector)
mitochondrial ribosomal protein S18A
Gene Symbol
MRPS18A
HGNC ID
HGNC:14515
ORF Size (aa)
591
RefSeq ID
NM_018135
RefSeq Synonyms
NM_018135, NM_001193343, BC010364,
Species
human
UniGene ID
Hs.520149
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.