human MRPL11 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human MRPL11.
shADV-215778
Ad-h-MRPL11-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human MRPL11 (mitochondrial ribosomal protein L11). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CGI-113; L11MT; MRP-L11
Description (Vector)
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified three transcript variants that encode different isoforms. Pseudogenes corresponding to this gene are found on chromosomes 5q and 12q.
Gene ID
65003
Gene Name (Vector)
mitochondrial ribosomal protein L11
Gene Symbol
MRPL11
HGNC ID
HGNC:14042
ORF Size (aa)
501
RefSeq ID
NM_170738
RefSeq Synonyms
NM_170739, NM_170738, NM_016050, BC108277, BC005002,
Species
human
UniGene ID
Hs.418450
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.