human MMP2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human MMP2.
shADV-215585
Ad-h-MMP2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human MMP2 (matrix metallopeptidase 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CLG4; CLG4A; MMP-2; MMP-II; MONA; TBE-1
Description (Vector)
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene.
Gene ID
4313
Gene Name (Vector)
matrix metallopeptidase 2
Gene Symbol
MMP2
HGNC ID
HGNC:7166
ORF Size (aa)
1983
ORF Size (bp)
1983 bp
RefSeq ID
NM_004530
RefSeq Synonyms
NM_004530, NM_001302510, NM_001302509, NM_001302508, NM_001127891, BC002576,
Species
human
UniGene ID
Hs.513617
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.