human MIF shRNA silencing Adenovirus

Name 
Ad-h-MIF-shRNA
Cat No 
shADV-215465
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human MIF.

shADV-215465
Ad-h-MIF-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human MIF (macrophage migration inhibitory factor (glycosylation-inhibiting factor)). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
epididymis secretory sperm binding protein; GIF; GLIF; Glycosylation-inhibiting factor; L-dopachrome isomerase; L-dopachrome tautomerase; macrophage migration inhibitory factor; macrophage migration inhibitory factor (glycosylation-inhibiting factor); MIF; MMIF; phenylpyruvate tautomerase
Description (eCommerce)
Macrophage migration inhibitory factor, or MIF, is a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. MIF plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. [taken from NCBI Entrez Gene (Gene ID: 4282)].
Description (Vector)
MIF encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways.
Gene ID
4282
Gene Name (eCommerce)
macrophage migration inhibitory factor
Gene Name (Vector)
macrophage migration inhibitory factor (glycosylation-inhibiting factor)
Gene Symbol
MIF
HGNC ID
HGNC:7097
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
348
Protein Name (eCommerce)
Macrophage migration inhibitory factor
RefSeq ID
NM_002415
RefSeq Synonyms
NM_002415, BC053376, BC022414, BC013976, BC008914, BC007676, BC000447,
Research Areas
Aging,Apoptosis,Cell Cycle,DNA Damage/Repair,Gene Expression,Immunology,Innate Immunity,Neurobiology,Signal Transduction
Research Areas (Faceted)
signal_transduction,cell_biology,cell_cycle,genetics,transcription_translation,immunology,neurobiology
Species
human
Target Sentence
Macrophage migration inhibitory factor, or MIF, is a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. MIF plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. [taken from NCBI Entrez Gene (Gene ID: 4282)].
UniGene ID
Hs.407995
UniProt ID (eCommerce)
P14174

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.