human MED23 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human MED23.
shADV-215256
Ad-h-MED23-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human MED23 (mediator complex subunit 23). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
130 kDa transcriptional co-activator; 133 kDa transcriptional co-activator; activator-recruited cofactor 130 kDa component; ARC130; cofactor required for Sp1 transcriptional activation subunit 3; CRSP complex subunit 3; CRSP130; CRSP133; CRSP3; DRIP130; hSur-2; Mediator complex subunit 23; mediator of RNA polymerase II transcription subunit 23; MRT18; Protein sur-2 homolog; SUR2; SUR-2; Transcriptional coactivator CRSP130; vitamin D3 receptor interacting protein; Vitamin D3 receptor-interacting protein complex 130 kDa component
Description (eCommerce)
CRSP3 is a subunit of the CRSP (cofactor required for SP1 activation) complex required for efficient transcriptional activation by the SP1 transcription factor. It has also been identified as a component of the mediator complex that bridges nuclear hormone receptors to RNA polymerase II. CRSP3 may also function as a metastasis suppressor through its transcriptional regulation of the metastasis suppressor, KiSS-1.
Description (Vector)
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein also acts as a metastasis suppressor. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Gene ID
9439
Gene Name (eCommerce)
mediator complex subunit 23
Gene Name (Vector)
mediator complex subunit 23
Gene Symbol
MED23
HGNC ID
HGNC:2372
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
4080
ORF Size (bp)
4080 bp
Protein Name (eCommerce)
Mediator of RNA polymerase II transcription subunit 23
RefSeq ID
NM_004830
RefSeq Synonyms
NM_015979, NM_004830, NM_001270522, NM_001270521, BC060759,
Research Areas
Gene Expression,Hedgehog Signaling,Metabolism/Metabolic Process,Neurobiology,Nuclear Receptor Coactivators,Signal Transduction,Transcription Factor/Regulator,Wnt Signaling
Research Areas (Faceted)
cell_biology,metabolism,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
CRSP3 is a subunit of the CRSP (cofactor required for SP1 activation) complex required for efficient transcriptional activation by the SP1 transcription factor. It has also been identified as a component of the mediator complex that bridges nuclear hormone receptors to RNA polymerase II. CRSP3 may also function as a metastasis suppressor through its transcriptional regulation of the metastasis suppressor, KiSS-1.
UniGene ID
Hs.29679
UniProt ID (eCommerce)
Q9ULK4
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.