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human MCM2 shRNA silencing Adenovirus

Name 
Ad-h-MCM2-shRNA
Cat No 
shADV-215175
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human MCM2.

shADV-215175
Ad-h-MCM2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human MCM2 (minichromosome maintenance complex component 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
BM28; CCNL1; cdc19; CDCL1; cell devision cycle-like 1; cyclin-like 1; D3S3194; DFNA70; DNA replication licensing factor MCM2; minichromosome maintenance deficient 2 (mitotin); minichromosome maintenance protein 2 homolog; MITOTIN; nuclear protein BM28
Description (eCommerce)
The MCM (Mini-Chromosome Maintenance) complex is a key component of the pre-replication complex involved in replication licensing which restricts DNA replication to only once per cell cycle. The MCM complex is a heterohexamer of MCM2, MCM3, MCM4, MCM5, MCM6, and MCM7. MCM2 interacts with the core MCM complex (MCM4, 6, and 7) to regulate its helicase activity.
Description (Vector)
MCM2 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7.
Gene ID
4171
Gene Name (eCommerce)
minichromosome maintenance complex component 2
Gene Name (Vector)
minichromosome maintenance complex component 2
Gene Symbol
MCM2
HGNC ID
HGNC:6944
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2715
ORF Size (bp)
2715 bp
Protein Name (eCommerce)
DNA replication licensing factor MCM2
RefSeq ID
NM_004526
RefSeq Synonyms
NM_004526, BC017490, BC017258, BC014272, BC007938, BC007670, BC006165,
Research Areas
Cell Cycle,Chromatin Remodeling,DNA Replication,Helicase Activity,Phospho-specific,Replication,Signal Transduction,Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
signal_transduction,cell_biology,cell_cycle,genetics,transcription_translation,cell_biology,cell_cycle,genetics,transcription_translation,cell_biology
Species
human
Target Sentence
The MCM (Mini-Chromosome Maintenance) complex is a key component of the pre-replication complex involved in replication licensing which restricts DNA replication to only once per cell cycle. The MCM complex is a heterohexamer of MCM2, MCM3, MCM4, MCM5, MCM6, and MCM7. MCM2 interacts with the core MCM complex (MCM4, 6, and 7) to regulate its helicase activity.
UniGene ID
Hs.477481
UniProt ID (eCommerce)
P49736

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.